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KMID : 0525720110160040237
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Journal of Chitin and Chitosan
2011 Volume.16 No. 4 p.237 ~ p.242
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Effects of Chitosanoligosaccharide on Nitric Oxide Production in Human Umbilical Vein Endothelial Cells
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Choi Ho-Jin
Kim Young-Ho
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Abstract
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Most adult-onset cardiovascular diseases are associated with age-related vascular dysfunction which is mainly a result of reduced NO production in endothelial cells. It was investigated that the effects of chitosan oligosaccharide (COS) on age-related vascular dysfunction. To this purpose, the antioxidant activity of COS, that is, the reduction of DPPH radicals and the inhibition of lipid peroxidation were measured. And the change in NO production content in cultured human umbilical vein endothelial cells were also measured. COS showed good antioxidant activity, that is, the reduction of DPPH radicals and the inhibition of lipid peroxidation. And chitosan oligosaccharide also increased the NO production. In this conclusion, COS was a good antioxidant and would have a protective effect on vascular dysfunction via increasing NO production in endothelial cells.
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KEYWORD
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chitosan oligosaccharide (COS), Lipid peroxidation, NO production
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